This study highlights novel genotype-driven metabolic adaptations in PM, laying the groundwork for targeted interventions ...

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MicroRNA-33a and microRNA-33b are encoded within the mammalian SREBF1 and SRBF2 genes, respectively, and both SREBF1 and ...

Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis ...

These findings highlight the dual roles of antioxidants in cancer. Their impact depends on cancer type, stage, and genetic alterations. In tumors where redox-sensitive signaling promotes cell death, ...

imageimageThere are no cellular or molecular biomarkers diagnostic of myalgic encephalomyelitis (also known as chronic fatigue syndrome [ME/CFS]). We find hundreds of blood-based traits are different, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This study presents and characterizes a Dnmt3a ...

Algorithms that constrain metabolic network models with enzyme levels to predict metabolic activity assume that changes in enzyme levels are indicative of flux variations. However, metabolic flux can ...

imageimageThe balance between cellular energy demand, expenditure, and anabolic processes to meet cells fundamental requirements remains debated. Using integrated temporal metabolomics and lipidomics, ...

The study explores the transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters.

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Enzymatic parameters are classically determined in vitro, under conditions that are far from those encountered in cells, casting doubt on their physiological relevance. We developed a generic approach ...